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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10815460 B1

PDFFull Text
Date of Patent:
Oct. 27, 2020

Filed:

Sep. 02, 2016

Three-dimensional differentiation of epiblast spheroids to kidney organoids models stage-specific epithelial physiology, morphogenesis, and disease

Applicant:

The Brigham and Women's Hospital, Inc., Boston, MA (US);

Inventors:

Benjamin S. Freedman, Boston, MA (US);

Joseph V. Bonventre, Boston, MA (US);

Assignee:

THE BRIGHAM AND WOMEN'S HOSPITAL, INC., Boston, MA (US);

Attorneys:

Nixon Peabody LLP

David S. Resnick

Teresa A. Ptashka

Primary Examiner:

Titilayo Moloye

Int. Cl.
CPC ...
C12N 5/071 (2010.01); G01N 33/50 (2006.01); A61K 35/44 (2015.01); A61K 35/22 (2015.01);
U.S. Cl.
CPC ...
C12N 5/0686 (2013.01); A61K 35/22 (2013.01); A61K 35/44 (2013.01); C12N 5/0684 (2013.01); G01N 33/5088 (2013.01); C12N 2500/90 (2013.01); C12N 2501/727 (2013.01); C12N 2501/999 (2013.01); C12N 2506/02 (2013.01); C12N 2506/03 (2013.01); C12N 2506/45 (2013.01); C12N 2513/00 (2013.01);
Abstract

Human pluripotent stem cells (hPSCs) have dual value as microphysiological laboratory models and regenerative therapeutics. hPSCs are epithelial cells, but the extent to which hPSCs and descendant epithelia can reconstitute lineage-specific functions remains poorly understood. Here the Inventors show that hPSCs in three-dimensional cultures and their differentiated descendants can functionally recapitulate tissue-specific epithelial morphogenesis, physiology, and disease.

Find Patent Forward Citations

Freedman, Benjamin. (2020). Three-dimensional differentiation of epiblast spheroids to kidney organoids models stage-specific epithelial physiology, morphogenesis, and disease (U.S. Patent No. 10815460). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10815460

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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