The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 27, 2020

Filed:

Mar. 20, 2017
Applicants:

Centre National DE LA Recherche Scientifique, Paris, FR;

Azienda Ospedaliera Papa Giovanni Xxiii, Bergamo, IT;

Universite DE Lausanne, Lausanne, CH;

Inventors:

Jean Kadouche, Paris, FR;

Jean-Pierre Mach, Bellevue, CH;

Olivier Michielin, Lausanne, CH;

Vincent Zoete, Morges, CH;

Justyna Iwaszkiewicz, Geneva, CH;

Martine Cerutti, Saint-Christol-lez-Ales, FR;

Sylvie Choblet, Ales, FR;

Josee Golay, Bergamo, IT;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/46 (2006.01); C07K 16/18 (2006.01); C12N 15/85 (2006.01); C12N 15/64 (2006.01); C07K 16/28 (2006.01);
U.S. Cl.
CPC ...
C07K 16/468 (2013.01); C07K 16/2833 (2013.01); C07K 16/2896 (2013.01); C07K 2317/31 (2013.01); C07K 2317/522 (2013.01); C07K 2317/55 (2013.01); C07K 2317/732 (2013.01);
Abstract

The invention relates to multispecific antibody constructs comprising Fab fragments having mutations at the interface of the CH1 and CL domains, said mutations preventing heavy chain/light chain mispairing.


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