The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 27, 2020
Filed:
Nov. 10, 2016
Applicant:
Fred Hutchinson Cancer Research Center, Seattle, WA (US);
Inventors:
Mesfin Gewe, Seattle, WA (US);
Roland K. Strong, Seattle, WA (US);
Martin Prlic, Seattle, WA (US);
Peter Rupert, Seattle, WA (US);
Thomas Spies, Seattle, WA (US);
Veronika Spies, Seattle, WA (US);
Assignee:
FRED HUTCHINSON CANCER RESEARCH CENTER, Seattle, WA (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07K 5/00 (2006.01); C07K 14/705 (2006.01); C07K 16/28 (2006.01); A61P 35/00 (2006.01); A61K 39/39 (2006.01); C07K 14/47 (2006.01); A61K 38/00 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/7056 (2013.01); A61K 39/39 (2013.01); A61P 35/00 (2018.01); C07K 14/47 (2013.01); C07K 14/4705 (2013.01); C07K 16/2833 (2013.01); C07K 16/2851 (2013.01); A61K 38/00 (2013.01); A61K 2039/505 (2013.01); A61K 2039/55516 (2013.01); C07K 2317/76 (2013.01); C07K 2319/00 (2013.01); C07K 2319/43 (2013.01); C07K 2319/50 (2013.01); C07K 2319/70 (2013.01); C07K 2319/74 (2013.01);
Abstract
Single chain, multimerized, and/or glycosylated NKG2D decoys are described. The NKG2D decoys have high affinity and avidity for surface bound and soluble NKG2D ligands and can be used to (i) identify NKG2D ligands; (ii) treat cancer, graft vs. host disease (GVHD), and inflammatory conditions; and (iii) potentiate an immune response against a vaccine as well as many other potential uses.