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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10815289 B1

PDFFull Text
Date of Patent:
Oct. 27, 2020

Filed:

Jun. 24, 2015

Fc-binding protein, method for producing said protein, antibody adsorbent using said protein, and method for separating antibody using said adsorbent

Applicant:

Tosoh Corporation, Yamaguchi, JP;

Inventors:

Yoshiharu Asaoka, Kanagawa, JP;

Toru Tanaka, Kanagawa, JP;

Yosuke Terao, Kanagawa, JP;

Naoki Yamanaka, Kanagawa, JP;

Natsuko Kizu, Kanagawa, JP;

Masaru Aoki, Kanagawa, JP;

Teruhiko Ide, Kanagawa, JP;

Assignee:

TOSOH CORPORATION, Yamaguchi, JP;

Attorney:

Greenblum & Bernstein, P.L.C.

Primary Examiner:

Chun W Dahle

Int. Cl.
CPC ...
C07K 1/00 (2006.01); C07H 21/02 (2006.01); C07H 21/04 (2006.01); C12P 21/06 (2006.01); C12N 1/20 (2006.01); C12N 5/00 (2006.01); C07K 16/00 (2006.01); C07K 14/735 (2006.01); C07K 1/22 (2006.01); C12P 21/02 (2006.01); C12N 15/09 (2006.01); C07K 16/06 (2006.01); B01D 15/38 (2006.01); B01J 20/281 (2006.01); G01N 33/68 (2006.01); G01N 30/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/70535 (2013.01); B01D 15/3809 (2013.01); C07K 1/22 (2013.01); C07K 16/00 (2013.01); C07K 16/065 (2013.01); C12N 15/09 (2013.01); C12P 21/02 (2013.01); G01N 30/482 (2013.01); G01N 33/6854 (2013.01); C07K 2317/10 (2013.01); C07K 2317/41 (2013.01); C07K 2317/732 (2013.01); G01N 2030/486 (2013.01); G01N 2400/02 (2013.01);
Abstract

Provided are: an Fc-binding protein having improved stability, particularly to heat and acid; a method for producing the protein; an antibody adsorbent using the protein; and a method for separating the antibodies using the adsorbent. Specifically provided are: an Fc-binding protein having improved stability to heat and acid, achieved by substituting an amino-acid residue in a specific position in the extracellular region of human FcyRIIIa with another specific amino acid; a method for producing the protein; an antibody adsorbent using the protein; and a method for separating the antibodies using the adsorbent.

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