The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 27, 2020
Filed:
Sep. 12, 2013
Applicant:
International Institute of Cancer Immunology, Inc., Suita-shi, Osaka, JP;
Inventors:
Haruo Sugiyama, Minoo, JP;
Fumihiro Fujiki, Hyogo, JP;
Assignee:
Primary Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); C07K 14/725 (2006.01); C12N 5/0783 (2010.01); A61K 35/17 (2015.01); C12Q 1/6886 (2018.01); C07K 16/28 (2006.01); C12Q 1/6881 (2018.01); G01N 33/569 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/7051 (2013.01); A61K 35/17 (2013.01); C07K 16/28 (2013.01); C12N 5/0636 (2013.01); C12Q 1/6881 (2013.01); C12Q 1/6886 (2013.01); G01N 33/56972 (2013.01); A61K 38/00 (2013.01); C12Q 2600/158 (2013.01); G01N 2333/4703 (2013.01); G01N 2333/70514 (2013.01);
Abstract
The present invention pertains to polynucleotides that encode CDR3 in TCR-[alpha] and TCR-[beta] chain genes of CD4helper T-cells that are specific to WT1 helper peptides having an amino acid sequence represented by SEQ ID NO: 123. The present invention further pertains to the peptides encoded by said polynucleotides. The present invention further pertains to CD4T cells into which TCR genes that contain said polynucleotides have been introduced, the induction of WT1-specific cytotoxic T-lymphocytes (CTLs) using the CD4T-cells, the treatment of cancer, etc.