The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 27, 2020
Filed:
Jun. 30, 2012
Carmelina Gemma, Bellevue, WA (US);
Paula C. Bickford, Ruskin, FL (US);
Kevin R. Nash, Seffner, FL (US);
Josh Morganti, Richmond, CA (US);
Adam Bachstetter, Lexington, KY (US);
Carmelina Gemma, Bellevue, WA (US);
Paula C. Bickford, Ruskin, FL (US);
Kevin R. Nash, Seffner, FL (US);
Josh Morganti, Richmond, CA (US);
Adam Bachstetter, Lexington, KY (US);
UNIVERSITY OF SOUTH FLORIDA, Tampa, FL (US);
THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS, Washington, DC (US);
Abstract
The subject invention pertains to the use of fractalkine (FKN, CX3CL1) and its receptor CX3CR1 for treatment of neuroinflammation and/or neurodegeneration. In one embodiment, the present invention provides a method for treatment of neuroinflammation and/or neurodegenerative diseases, comprising: administering, to cells of a subject in need of such treatment, an adeno-associated virus that comprises a functional fractalkine gene operably linked to transcriptional control elements. In one embodiment, the subject invention is used to treat or ameliorate Parkinson's disease. The present invention can also be used to treat or ameliorate neuroinflammatory and/or neurodegenerative diseases including, but not limited to, Alzheimer's disease, epilepsy, aging, and traumatic brain injury.