The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 27, 2020

Filed:

Jul. 13, 2017
Applicant:

Bristol-myers Squibb Company, Princeton, NJ (US);

Inventors:

Jeremy M. Richter, Yardley, PA (US);

Xiaojun Zhang, Furlong, PA (US);

Eldon Scott Priestley, Yardley, PA (US);

Assignee:

Bristol-Myers Squibb Company, Princeton, NJ (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 413/10 (2006.01); C07D 417/14 (2006.01); C07D 403/04 (2006.01); C07D 413/04 (2006.01); C07D 471/04 (2006.01); C07D 417/04 (2006.01); A61P 7/02 (2006.01); C07D 403/10 (2006.01); C07D 417/10 (2006.01);
U.S. Cl.
CPC ...
C07D 413/10 (2013.01); A61P 7/02 (2018.01); C07D 403/04 (2013.01); C07D 403/10 (2013.01); C07D 413/04 (2013.01); C07D 417/04 (2013.01); C07D 417/10 (2013.01); C07D 417/14 (2013.01); C07D 471/04 (2013.01);
Abstract

Disclosed are compounds of Formulas (I), (II), (III), (IV), (V), (VI), (VII), or (VIII): (I) (II) (III) (IV) (V) (VI) (VII) (VIII) or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate or prodrug thereof, wherein Ris a monocyclic heteroaryl group substituted with zero to 3 R; and R, R, R, R, and n are defined herein. Also disclosed are methods of using such compounds as PAR4 inhibitors, and pharmaceutical compositions comprising such compounds. These compounds are useful in inhibiting or preventing platelet aggregation, and are useful for the treatment of a thromboembolic disorder or the primary prophylaxis of a thromboembolic disorder.


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