The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 27, 2020

Filed:

Jul. 22, 2016
Applicants:

Inserm (Institut National DE LA Sante ET DE LA Recherche Medicale), Paris, FR;

Universite Nice Sophia Antipolis, Nice, FR;

Centre National DE LA Recherche Scientifique (Cnrs), Paris, FR;

Inventors:

Stephane Rocchi, Nice, FR;

Rachid Benhida, Nice, FR;

Robert Ballotti, Nice, FR;

Magali Plaisant, Nice, FR;

Cyril Ronco, Nice, FR;

Antoine Millet, Nice, FR;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 277/46 (2006.01); A61K 31/426 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
C07D 277/46 (2013.01); A61K 31/426 (2013.01); A61P 35/00 (2018.01);
Abstract

The present invention relates to compound of general formula (I) Ris selected from H, aryl and alkyl, Ris selected from H, alkyl, aryl and CO—R; Ris selected from H, halogen, alkyl, alkenyl, alkynyl, aryl, NHR, NRR, ORand SR; Ris selected from (C-C) alkyl, (C-C) alkenyl, (C-C) alkynyl and (C-C) aryl, Rrepresents H, R, aryl, OH, OR, O-aryl, SH, SR, S-aryl, CN, NO, CF, COOR, SONRR, CONRR, NH, NHR, NH-aryl, NRR, NHCORor aminoacyl; Ris alkyl optionally substituted with halogen, OH, SH, NH, O-alkyl, S-alkyl, NH-alkyl or NH-di(alkyl); Rand Ridentical or different are H or alkyl optionally substituted with halogen, OH, SH, NH, O-alkyl, S-alkyl, NH-alkyl or NH-di (alkyl), their pharmaceutically acceptable salts and/or isomers, tautomers, solvates or isotopic variations thereof. The compounds are useful for the treatment of cancers.


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