The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 27, 2020
Filed:
Apr. 17, 2020
Applicant:
Api Corporation, Tokyo, JP;
Inventors:
Naoyuki Watanabe, Fukuoka, JP;
Takanobu Iura, Kanagawa, JP;
Hideki Oomiya, Fukuoka, JP;
Masaki Nagahama, Fukuoka, JP;
Assignee:
API CORPORATION, Tokyo, JP;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61P 43/00 (2006.01); A61P 3/06 (2006.01); A61K 31/47 (2006.01); C07D 215/14 (2006.01); C07B 61/00 (2006.01); C12P 17/12 (2006.01);
U.S. Cl.
CPC ...
C07D 215/14 (2013.01); C12P 17/12 (2013.01); A61K 31/47 (2013.01); C07B 61/00 (2013.01);
Abstract
Production of pitavastatin calcium safely on an industrial scale with a high yield and high selectivity at low cost. A method of producing pitavastatin calcium including step (i) for acetalizing a compound represented by the formula (1) to give a compound represented by the formula (3), step (ii) for reacting a compound represented by the formula (3) with an acid to give a compound represented by the formula (4), and step (iii) for hydrolyzing a compound represented by the formula (4) and reacting same with a calcium compound.