The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 27, 2020
Filed:
Jul. 14, 2016
University of Iowa Research Foundation, Iowa City, IA (US);
David F. Wiemer, Iowa City, IA (US);
Rocky J. Barney, Iowa City, IA (US);
Andrew Wiemer, Storrs, CT (US);
David F. Wiemer, Iowa City, IA (US);
Rocky J. Barney, Iowa City, IA (US);
Andrew Wiemer, Storrs, CT (US);
University of Iowa Research Foundation, Iowa City, IA (US);
University of Connecticut, Farmington, CT (US);
Abstract
The invention provides a drug conjugate comprising: 1) a therapeutic agent that comprises a phosphate, phosphonate, carboxy, or phosphoramidate group, and 2) a fluorescent group linked to the phosphate, phosphonate, carboxy, or phosphoramidate group to form the corresponding ester and salts thereof. The conjugates are useful for therapy and as probes. The invention also provides therapeutic methods for treating diseases with conjugates of the invention as well as methods for determining optimal dosages of a conjugate or a therapeutic agent for a given patient using a conjugate of the invention.