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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10813950 B1

PDFFull Text
Date of Patent:
Oct. 27, 2020

Filed:

Dec. 02, 2011

Immunotherapy using allo-nkt cells, cells for immunotherapy in which alpha chain of t-cell receptor (tcr) gene has been rearranged to uniform vα-jα, and banking of nkt cells derived from said cells

Applicants:

Masaru Taniguchi, Yokohama, JP;

Haruhiko Koseki, Yokohama, JP;

Hiroshi Watarai, Yokohama, JP;

Shin-ichiro Fujii, Yokohama, JP;

Inventors:

Masaru Taniguchi, Yokohama, JP;

Haruhiko Koseki, Yokohama, JP;

Hiroshi Watarai, Yokohama, JP;

Shin-ichiro Fujii, Yokohama, JP;

Assignee:

RIKEN, Wako, JP;

Attorney:

Leydig, Voit & Mayer, Ltd.

Primary Examiner:

G R Ewoldt

Assistant Examiner:

Marianne DiBrino

Int. Cl.
CPC ...
A61K 35/17 (2015.01); C12N 5/0783 (2010.01); C07K 14/725 (2006.01); A61K 45/06 (2006.01); A61K 31/7028 (2006.01); C12N 15/85 (2006.01);
U.S. Cl.
CPC ...
A61K 35/17 (2013.01); A61K 31/7028 (2013.01); A61K 45/06 (2013.01); C07K 14/7051 (2013.01); C12N 5/0646 (2013.01); C12N 15/85 (2013.01);
Abstract

The present invention provides an agent for an immunocyte therapy, comprising an NKT cell obtained by differentiating in vitro a cell having the α-chain region of the T cell receptor gene rearranged to uniform Vα-Jα in an NKT cell receptor-specific way, wherein an administration subject is an allogenic individual having MHC gene loci including at least one locus having a genotype different from that of the NKT cell. In addition, the present invention provides a bank of a human cell or an NKT cell derived from said cell, wherein the α-chain region of a T cell receptor (TCR) gene has been rearranged to uniform Vα-Jα. The agent and cell bank of the present invention are useful for the prophylaxis and/or treatment of cancer, infection, an allergic disease or an autoimmune disease.

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