The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 27, 2020

Filed:

Feb. 23, 2018
Applicants:

University of South Florida, Tampa, FL (US);

Transgenex Nanobiotech, Inc., Lutz, FL (US);

Inventors:

Subhra Mohapatra, Lutz, FL (US);

Shyam S. Mohapatra, Lutz, FL (US);

Mark Howell, Tampa, FL (US);

Rajesh Nair, Tampa, FL (US);

Assignees:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/517 (2006.01); A61P 35/00 (2006.01); A61K 31/496 (2006.01);
U.S. Cl.
CPC ...
A61K 31/517 (2013.01); A61P 35/00 (2018.01); A61K 31/496 (2013.01); A61K 2300/00 (2013.01);
Abstract

Disclosed herein are compositions and methods for treating cancer. Further provided herein are compositions and methods for reducing, inhibiting, or preventing resistance of cancer to tyrosine kinase inhibitors. The methods may include administering an anti-resistance agent such as a CYP51A1 inhibitor or an agonist of miRNA-764 (SEQ ID NO: 4) to a subject. A tyrosine kinase inhibitor may also be administered to the subject in addition to the anti-resistance agent.


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