The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 20, 2020

Filed:

Feb. 23, 2018
Applicant:

Access Medical Systems, Ltd., Palo Alto, CA (US);

Inventors:

Robert F. Zuk, Menlo Park, CA (US);

Hong Tan, San Jose, CA (US);

Qing Xia, Sunnyvale, CA (US);

Pu Li, San Jose, CA (US);

Haode Chen, Shanghai, CN;

Heng Wu, Shanghai, CN;

Assignee:

ACCESS MEDICAL SYSTEMS, LTD., Palo Alto, CA (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/543 (2006.01); G01N 33/533 (2006.01); G01N 33/53 (2006.01); G01N 33/58 (2006.01);
U.S. Cl.
CPC ...
G01N 33/54306 (2013.01); G01N 33/53 (2013.01); G01N 33/533 (2013.01); G01N 33/5306 (2013.01); G01N 33/543 (2013.01); G01N 33/582 (2013.01);
Abstract

The present invention is directed to methods for increasing sensitivities of immunoassays. The invention utilizes an acid elution condition that preferentially elute specifically bound immune complexes over non-specifically bound complexes from a solid phase, and designs immunoassay protocols that improve the ratio of specific binding to non-specific binding and thereby improving assay sensitivity. The protocol determines the signal of the labeled immunocomplexes eluted from a solid phase.


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