logo

For the Inventor, By the Inventor

The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10808335 B1

PDFFull Text
Date of Patent:
Oct. 20, 2020

Filed:

Sep. 04, 2018

Electrospun cationic nanofibers and methods of making and using the same

Applicant:

Duke University, Durham, NC (US);

Inventors:

Bruce A. Sullenger, Durham, NC (US);

Hemraj A. Juwarker, Durham, NC (US);

Kam W. Leong, Durham, NC (US);

Jennifer Gamboa Jackman, Durham, NC (US);

Assignee:

Duke University, Durham, NC (US);

Attorney:

Quarles & Brady LLP

Primary Examiner:

Nizal S Chandrakumar

Int. Cl.
CPC ...
D01F 6/22 (2006.01); B29C 48/88 (2019.01); D01D 5/00 (2006.01); D01F 6/36 (2006.01); D01F 6/42 (2006.01); D06M 14/10 (2006.01); A61L 15/46 (2006.01); D06M 15/285 (2006.01); D06M 15/00 (2006.01); A61L 15/24 (2006.01); A61L 15/44 (2006.01); A61L 27/16 (2006.01); A61L 27/54 (2006.01); D06M 15/59 (2006.01); D06M 15/61 (2006.01); D06M 101/20 (2006.01); D06M 101/26 (2006.01);
U.S. Cl.
CPC ...
D01F 6/22 (2013.01); A61L 15/24 (2013.01); A61L 15/44 (2013.01); A61L 15/46 (2013.01); A61L 27/16 (2013.01); A61L 27/54 (2013.01); B29C 48/88 (2019.02); D01D 5/003 (2013.01); D01F 6/36 (2013.01); D01F 6/42 (2013.01); D06M 14/10 (2013.01); D06M 15/00 (2013.01); D06M 15/285 (2013.01); D06M 15/59 (2013.01); D06M 15/61 (2013.01); A61L 2300/404 (2013.01); A61L 2300/41 (2013.01); A61L 2400/12 (2013.01); D06M 2101/20 (2013.01); D06M 2101/26 (2013.01); D06M 2400/01 (2013.01); D10B 2509/022 (2013.01);
Abstract

Methods of making polycationic nanofibers by grafting cationic polymers onto electrospun neutral nanofibers and polycationic nanofibers produced by the methods are provided herein. In addition, methods of using the polycationic nanofibers to reduce inflammation, to adsorb anionic compounds such as heparin or nucleic acids, to inhibit the growth of microbes or inhibit the formation of a biofilm are also provided. The polycationic nanofibers may be in a mesh and may be included in a medical device, wound dressing, bandage, or as part of a graft.

Find Patent Forward Citations

Loading…