The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 20, 2020
Filed:
Jul. 06, 2016
Applicants:
Phio Pharmaceuticals Corp., Marlborough, MA (US);
Synaerion Therapeutics, Berwyn, PA (US);
Inventors:
Michael Byrne, Natick, MA (US);
Antonella Favit-VanPelt, Norwell, MA (US);
Assignees:
Phio Pharmaceuticals Corp., Marlborough, MA (US);
Synaerion Therapeutics, Berwyn, PA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/113 (2010.01); C12N 15/11 (2006.01); A61P 25/28 (2006.01); A61K 31/713 (2006.01); A61K 31/36 (2006.01); A61K 31/444 (2006.01);
U.S. Cl.
CPC ...
C12N 15/113 (2013.01); A61K 31/713 (2013.01); A61P 25/28 (2018.01); C12N 15/111 (2013.01); A61K 31/36 (2013.01); A61K 31/444 (2013.01); A61K 2300/00 (2013.01); C12N 2310/11 (2013.01); C12N 2310/315 (2013.01); C12N 2320/31 (2013.01);
Abstract
In one aspect, the disclosure provides methods for treating a neurodegenerative disorder, comprising administering to a subject in need thereof a therapeutically effective amount of a nucleic acid molecule and a therapeutically effective amount of a small molecule that activates NF-κB p65 and increases expression of manganese superoxide dismutase (MnSOD/SOD2) and/or expression of a related protein or enzyme.