The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 20, 2020
Filed:
Jun. 25, 2019
Applicant:
Nof Corporation, Tokyo, JP;
Inventors:
Takuma Tsubusaki, Kawasaki, JP;
Yuji Yamamoto, Kawasaki, JP;
Assignee:
NOF CORPORATION, Tokyo, JP;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C08F 8/12 (2006.01); A61K 39/395 (2006.01); A61K 45/00 (2006.01); A61K 47/22 (2006.01); C07K 16/00 (2006.01); A61K 47/50 (2017.01); C07C 45/36 (2006.01); C07K 16/18 (2006.01); C07K 19/00 (2006.01); C07D 405/14 (2006.01); C07D 317/28 (2006.01); C07D 405/06 (2006.01);
U.S. Cl.
CPC ...
C08F 8/12 (2013.01); A61K 39/395 (2013.01); A61K 45/00 (2013.01); A61K 47/22 (2013.01); A61K 47/50 (2017.08); C07C 45/36 (2013.01); C07K 16/00 (2013.01); C07K 16/18 (2013.01); C07K 19/00 (2013.01); C07D 317/28 (2013.01); C07D 405/06 (2013.01); C07D 405/14 (2013.01); C07K 2317/24 (2013.01); C07K 2317/30 (2013.01); C07K 2317/50 (2013.01); C07K 2317/90 (2013.01); C07K 2317/92 (2013.01);
Abstract
An antibody-drug conjugate having a cyclic benzylidene acetal linker represented by formula (1) or formula (2), wherein Y is an antibody; D is a drug; Rand Rare each independently a hydrogen atom or a hydrocarbon group; R, R, Rand Rare each independently an electron-withdrawing or electron-donating substituent or a hydrogen atom; s is 1 or 2, t is 0 or 1, and s+t is 1 or 2; w is an integer of 1 to 20; and Zand Zare each independently a selected divalent spacer: