The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 20, 2020
Filed:
Jan. 06, 2017
Applicant:
Csl Behring Lengnau Ag, Lengnau, CH;
Inventors:
Arna Andrews, Kew East, AU;
Con Panousis, Bundoora, AU;
Kerstin Emmrich, Preston, AU;
Michael Wilson, Elwood, AU;
Steve Dower, Fitzroy North, AU;
Matthew Hardy, Doreen, AU;
Dallas Hartman, Niddrie, AU;
Assignee:
CSL BEHRING LENGNAU AG, Lengnau, CH;
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/755 (2006.01); C07K 16/46 (2006.01); A61K 47/65 (2017.01); A61K 31/718 (2006.01); A61K 31/727 (2006.01); A61K 31/728 (2006.01); A61K 38/37 (2006.01); A61K 47/10 (2017.01); A61P 7/04 (2006.01); A61K 38/39 (2006.01); C07K 14/76 (2006.01); C07K 14/79 (2006.01); C07K 16/36 (2006.01); C12N 15/62 (2006.01); A61K 38/00 (2006.01); A61K 35/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/755 (2013.01); A61K 31/718 (2013.01); A61K 31/727 (2013.01); A61K 31/728 (2013.01); A61K 38/39 (2013.01); A61K 47/10 (2013.01); A61K 47/65 (2017.08); C07K 14/76 (2013.01); C07K 14/79 (2013.01); C07K 16/36 (2013.01); C07K 16/46 (2013.01); C12N 15/62 (2013.01); A61K 35/00 (2013.01); A61K 38/00 (2013.01);
Abstract
The present invention provides a modified polypeptide which binds Factor VIII. The modified polypeptide comprises a sequence as shown in SEQ ID NO:3 in which the sequence comprises at least one modification at a position selected from the group consisting of L18, V42, K149, N248, S279, V320, T325, Q395 and K418 such that the modified polypeptide binds to Factor VIII with an off rate lower than a reference polypeptide comprising an unmodified SEQ ID NO:3.