The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 20, 2020
Filed:
Sep. 22, 2017
The Usa, As Represented BY the Secretary, Dept. of Health and Human Services, Bethesda, MD (US);
Codagenix, Inc., Farmingdale, NY (US);
Cyril Lenouen, Bethesda, MD (US);
Ursula J. Buchholz, Silver Spring, MD (US);
Peter L. Collins, Silver Spring, MD (US);
Steffen Mueller, Stony Brook, NY (US);
The USA, as represented by the Secretary, Dept. of Health and Human Services, Bethesda, MD (US);
Codagenix, Inc., Farmingdale, NY (US);
Abstract
Reported herein are presumptively de-attenuating mutations that are useful, either individually or in combinations that may include other known mutations, in producing recombinant strains of human respiratory syncytial virus (RSV) exhibiting attenuation phenotypes. Also described herein is a novel RSV construct, Min_L-NPM2-1(N88K)L, which exhibits an attenuated phenotype, is stable and is as immunogenic as wild type RSV. The recombinant RSV strains described here are suitable for use as live-attenuated RSV vaccines. Exemplary vaccine candidates are described. Also provided are polynucleotide sequences capable of encoding the described viruses, as well as methods for producing and using the viruses.