The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 20, 2020
Filed:
Aug. 10, 2017
The United States of America, As Represented BY the Secretary, Dept. of Health and Human Services, Bethesda, MD (US);
The University of Tokyo, Tokyo, JP;
New England Biolabs, Inc., Ipswich, MA (US);
James Inglese, Bethesda, MD (US);
Patricia Dranchak, Gaithersburg, MD (US);
Ryan MacArthur, Odenton, MD (US);
Hiroaki Suga, Tokyo, JP;
Hao Yu, Tokyo, JP;
Clotilde Carlow, South Hamilton, MA (US);
Zhiru Li, Lexington, MA (US);
The United States of America, as represented by the Secretary, Department of Health and Human Services, Bethesda, MD (US);
The University of Tokyo, Tokyo, JP;
New England Biolabs, Inc., Ipswich, MA (US);
Abstract
Disclosed herein are isolated peptides inhibit activity of a cofactor-independent phosphoglycerate mutase. In some examples, the isolated peptide is 6-20 amino acids long and includes the amino acid sequence of any one of SEQ ID NOs: 1-22 or 54, an analog or derivative thereof, or a pharmaceutically acceptable salt or ester thereof. In some examples, the peptide is a cyclic peptide with an N-terminal ring of 6-15 amino acids (for example, 6-10 amino acids) and a C-terminal linear portion of 1-9 amino acids (for example, 3-8 amino acids. Also disclosed h are methods of treating or inhibiting an infection in a subject, including administering to the subject an effective amount of a composition including one of more of the disclosed peptides, or analogs or derivative thereof, or pharmaceutically acceptable salts or esters thereof.