The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 20, 2020
Filed:
Nov. 24, 2018
Guangdong University of Technology, Guangzhou, CN;
The Centre National DE LA Recherche Scientifique, Paris, FR;
Yan Liu, Guangzhou, CN;
Xingguo Liu, Guangzhou, CN;
Weixin Zhang, Guangzhou, CN;
Daya Huang, Guangzhou, CN;
Meijie Huang, Guangzhou, CN;
Dean Wang, Guangzhou, CN;
Ju Huang, Guangzhou, CN;
Siwei Shu, Guangzhou, CN;
Michel Nguyen, Toulouse, FR;
Anne Robert, Toulouse, FR;
Bernard Meunier, Toulouse, FR;
Other;
Abstract
A tetradentate chelating monoquinoline derivative with a structure as shown in formula (I) is able to specifically chelate redox active metal ions like copper ions that are dis-regulated in neurodegenerative diseases (Alzheimer's disease, Huntington's disease, Parkinson's disease, and amyotrophic lateral sclerosis), or copper accumulation disease like Wilson's disease. The binding constants of these derivatives for zinc are 6-10 orders of magnitude below that ones for copper, and these derivatives have a good capability of reducing an oxidative stress. The method for preparing the derivative is simple and the derivatives have good application prospects in manufacturing drugs for neurodegenerative diseases and diseases related to disorder of copper metabolism.