The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 20, 2020
Filed:
Mar. 25, 2019
Metabasis Therapeutics, Inc., San Diego, CA (US);
Jorge E. Gomez-Galeno, San Diego, CA (US);
Raja K. Reddy, San Diego, CA (US);
Paul D. Van Poelje, La Jolla, CA (US);
Robert Huerta Lemus, Escondido, CA (US);
Thanh Huu Nguyen, Solana Beach, CA (US);
Matthew P. Grote, Carlsbad, CA (US);
Qun Dang, San Diego, CA (US);
Scott J. Hecker, Del Mar, CA (US);
Venkat Reddy Mali, San Diego, CA (US);
Mingwei Chen, San Diego, CA (US);
Zhili Sun, San Diego, CA (US);
Serge Henri Boyer, San Diego, CA (US);
Haiqing Li, San Diego, CA (US);
William Craigo, San Diego, CA (US);
Metabasis Therapeutics, Inc., San Diego, CA (US);
Abstract
The present invention provides for novel compounds of Formula (I) and pharmaceutically acceptable salts and co-crystals thereof which have glucagon receptor antagonist or inverse agonist activity. The present invention further provides for pharmaceutical compositions comprising the same as well as methods of treating, preventing, delaying the time to onset or reducing the risk for the development or progression of a disease or condition for which one or more glucagon receptor antagonist is indicated, including Type I and II diabetes, insulin resistance and hyperglycemia. The present invention also provides for processes of making the compounds of Formula I, including salts and co-crystals thereof and pharmaceutical compositions comprising the same.