The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 20, 2020
Filed:
Aug. 07, 2017
Wisconsin Alumni Research Foundation, Madison, WI (US);
Helen E. Blackwell, Middleton, WI (US);
Christine E. McInnis, Madison, WI (US);
Wisconsin Alumni Research Foundation, Madison, WI (US);
Abstract
Non-lactone carbocyclic modulators of bacterial quorum sensing. Pharmaceutical composition containing such modulators. Methods employing such modulators for modulation of quorum sensing. Compounds are exemplified by those of formula:A-[Z]-L1-[Y]—NH-L2-HG,where A is an optionally substituted aryl or heteroaryl group having one or two 5- or 6-member rings with up to 1-3 heteroatoms in a ring, or a substituted or unsubstituted C1-C12 acyclic aliphatic group and HG is an optionally substituted cyclopentyl group. Compounds include those where n is 1 or 0, Z is —CO—, —O—CO—, —CO—O—, —NH—CO—, —CO—NH—, —NH—CO—NH—, —O—, —S—, or —NH, Y is —NH—CO—, —CO—CH—C(Y1)-, or —SO—, where Y1 is —OH, —SH, —NHor —F; and L1 and L2 independently are —[CH]p1- and —[CH]p2-, where p1 and p2, independently, are 0 or integers ranging from 1-3.