The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 20, 2020
Filed:
Jun. 05, 2018
National Cheng Kung University, Tainan, TW;
National Cheng Kung University Hospital, Tainan, TW;
National Taiwan Normal University, Taipei, TW;
Wu-Chou Su, Tainan, TW;
Hai-Wen Chen, Tainan, TW;
Tsung-Lin Tsai, Tainan, TW;
Dar-Bin Shieh, Tainan, TW;
Chia-Chun Chen, Taipei, TW;
NATIONAL CHENG KUNG UNIVERSITY, Tainan, TW;
NATIONAL CHENG KUNG UNIVERSITY HOSPITAL, Tainan, TW;
Abstract
A pharmaceutical composition includes a plurality of metal nanoparticles and at least one therapeutic agent. Each of the metal nanoparticles includes a core and a stabilizing agent coated on a surface of the core. The at least one therapeutic agent is attached to the stabilizing agent of the metal nanoparticles. Each of the therapeutic agent is an amphiphilic compound and has at least one hydrophobic chain interacting with the stabilizing agent. The pharmaceutical composition may further include a polymer shell encapsulating the metal nanoparticles and the therapeutic agent for enabling controlled release of the therapeutic agent. The pharmaceutical compositions are bifunctional and may be used for diagnosing and treating cancer. Methods for using the pharmaceutical compositions in conjunction with radiation therapy to diagnose and treat cancer are also provided.