The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 20, 2020
Filed:
Dec. 21, 2017
Applicant:
Incyte Corporation, Wilmington, DE (US);
Inventors:
Liang Lu, Hockessin, DE (US);
Wenyu Zhu, Media, PA (US);
Ding-Quan Qian, Newark, DE (US);
Kaijiong Xiao, Clark, NJ (US);
Assignee:
Incyte Corporation, Wilmington, DE (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/39 (2006.01); A61P 37/00 (2006.01); A61P 37/04 (2006.01); A61P 35/00 (2006.01); A61K 45/06 (2006.01); C07D 213/81 (2006.01); C07D 263/57 (2006.01); C07D 413/06 (2006.01); C07D 413/14 (2006.01); C07D 471/04 (2006.01); C07D 519/00 (2006.01); G01N 33/50 (2006.01); A61K 39/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/39 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01); A61P 37/00 (2018.01); A61P 37/04 (2018.01); C07D 213/81 (2013.01); C07D 263/57 (2013.01); C07D 413/06 (2013.01); C07D 413/14 (2013.01); C07D 471/04 (2013.01); C07D 519/00 (2013.01); G01N 33/5026 (2013.01); A61K 2039/55511 (2013.01);
Abstract
Compositions and methods for inducing PD-L1 internalization are disclosed. The methods include reducing the amount of cell surface PD-L1 by contacting a cell expressing PD-L1 with a compound that binds to cell surface PD-L1 and induces PD-L1 internalization. Compounds that induce PD-L1 internalization can be used to enhance, stimulate and/or increase an immune response and treat a PD-1-related disease or condition.