The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 20, 2020
Filed:
Nov. 20, 2018
Case Western Reserve University, Cleveland, OH (US);
Mukesh Agarwal, Solon, OH (US);
David Wald, Shaker Heights, OH (US);
Mahesh Gundluru, Lexington, KY (US);
Goutam Karan, Lexington, KY (US);
Zhiqiang Xia, Lexington, KY (US);
CASE WESTERN RESERVE UNIVERSITY, Cleveland, OH (US);
Abstract
The present application relates to securinine or norsecurinine analogues that, when administered to immature myeloid cells, promote differentiation of these cells to mature cells that do not readily proliferate. Therefore, the agents are useful in the treatment of myeloid disorders including myeloproliferative disorders, acute myeloid leukemia, and autoimmune diseases. The agents may also be used as a myeloablative agent in conjunction with a bone marrow transplant or stem cell therapy.