The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 20, 2020

Filed:

Mar. 14, 2014
Applicant:

The Johns Hopkins University, Baltimore, MD (US);

Inventors:

Michela Gallagher, Baltimore, MD (US);

Rebecca Haberman, Baltimore, MD (US);

Ming Teng Koh, Baltimore, MD (US);

Arnold Bakker, Baltimore, MD (US);

Assignee:

The Johns Hopkins University, Baltimore, MD (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/4015 (2006.01); A61P 25/28 (2006.01); A61K 31/19 (2006.01); A61K 45/06 (2006.01); A61B 5/00 (2006.01); C12Q 1/6883 (2018.01); G01N 33/68 (2006.01); G01N 33/74 (2006.01); G09B 3/06 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4015 (2013.01); A61B 5/4088 (2013.01); A61K 31/19 (2013.01); A61K 45/06 (2013.01); A61P 25/28 (2018.01); C12Q 1/6883 (2013.01); G01N 33/6896 (2013.01); G01N 33/74 (2013.01); G09B 3/06 (2013.01); C12Q 2600/118 (2013.01); C12Q 2600/158 (2013.01); G01N 2333/4703 (2013.01); G01N 2333/575 (2013.01); G01N 2800/2814 (2013.01); G01N 2800/52 (2013.01);
Abstract

This invention relates to methods and compositions for treating cognitive impairment associated with central nervous system (CNS) disorders. In particular, it relates to the use of inhibitors of synaptic vesicle glycoprotein 2A (SV2A), alone or in combination with valproate, in treating cognitive impairment associated with central nervous system (CNS) disorders in a subject in need or at risk thereof, including, without limitation, subjects having or at risk for age-related cognitive impairment.


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