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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10806715 B1

PDFFull Text
Date of Patent:
Oct. 20, 2020

Filed:

Oct. 23, 2017

Gold nanoparticle based formulation for use in cancer therapy

Applicant:

Council of Scientific & Industrial Research, New Delhi, IN;

Inventors:

Rajesh Kotcherlakota, Hyderabad, IN;

Sudip Mukherjee, Hyderabad, IN;

Chitta Ranjan Patra, Hyderabad, IN;

Vijaya Gopal, Hyderabad, IN;

Assignee:

Council of Scientific & Industrial Research, New Delhi, IN;

Attorney:

Dinsmore & Shohl LLP

Primary Examiner:

Amy H Bowman

Int. Cl.
CPC ...
A61K 48/00 (2006.01); C07H 21/04 (2006.01); A61K 31/351 (2006.01); A61K 47/62 (2017.01); A61K 47/69 (2017.01); A61K 31/713 (2006.01); A61K 31/24 (2006.01); A61K 31/704 (2006.01); A61K 33/24 (2019.01); A61P 35/00 (2006.01); A61K 31/7105 (2006.01); A61K 33/243 (2019.01); A61K 9/00 (2006.01); A61K 31/519 (2006.01);
U.S. Cl.
CPC ...
A61K 31/351 (2013.01); A61K 31/24 (2013.01); A61K 31/704 (2013.01); A61K 31/713 (2013.01); A61K 31/7105 (2013.01); A61K 33/24 (2013.01); A61K 47/62 (2017.08); A61K 47/6923 (2017.08); A61K 47/6929 (2017.08); A61P 35/00 (2018.01); A61K 9/0019 (2013.01); A61K 31/519 (2013.01); A61K 33/243 (2019.01);
Abstract

The current invention relates to development of new formulation containing gold nanoparticles (AuNPs) with bi-functional recombinant fusion proteins TRAF(C) for the delivery of anticancer drugs and nucleic acids to HER2+ cancers. Using the combinatorial approach, we designed gold nanoparticle-based targeted drug delivery system (TDDS) or (Au-TR-DX-si) by combining AuNPs with bi-functional recombinant fusion protein TRAF(C) (TR), doxorubicin (DX) and siRNA (si). The recombinant protein based gold nanoparticles formulations are stable and homogenous as revealed by several physicochemical studies. In addition, the engineered fusion protein TRAF (C) has the ability to target selectively to HER2+ receptors overexpressed in ovarian cancer cells (SK-OV-3).

Find Patent Forward Citations

Kotcherlakota, Rajesh. (2020). Gold nanoparticle based formulation for use in cancer therapy (U.S. Patent No. 10806715). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/10806715

Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile

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