The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 20, 2020

Filed:

Dec. 07, 2016
Applicant:

Apse, Inc., St. Louis, MO (US);

Inventors:

John L. Killmer, St. Louis, MO (US);

Juan Pedro Humberto Arhancet, St. Louis, MO (US);

Patrick D. McLaughlin, St. Louis, MO (US);

Assignee:

APSE, INC., St. Lois, MO (US);

Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/04 (2006.01); A01N 63/00 (2020.01); C07K 14/005 (2006.01); C12N 15/113 (2010.01); C12N 15/70 (2006.01); C12N 15/81 (2006.01);
U.S. Cl.
CPC ...
A01N 63/00 (2013.01); C07K 14/005 (2013.01); C12N 15/113 (2013.01); C12N 15/1131 (2013.01); C12N 15/70 (2013.01); C12N 15/81 (2013.01); C12N 2310/14 (2013.01); C12N 2770/00042 (2013.01); C12N 2795/16023 (2013.01); C12N 2795/18023 (2013.01);
Abstract

The invention describes recombinant DNA sequences transcribed into RNA constructs capable of forming Virus Like Particles (VLPs) suitable for insect control applications. Specifically, the disclosure provides a method for controlling target insects comprising, transforming a microbial host with a first DNA sequence comprising a gene encoding a bacteriophage capsid protein and a second DNA sequence encoding an RNA transcript comprising at least one bacteriophage pac sequence coupled to an RNAi precursor sequence, inducing the microbial host to express the first and second DNA sequences, isolating virus-like-particles (VLPs) comprising the capsid protein and RNAi precursor from the microbial host, and contacting the isolated VLPs with the target insects.


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