The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 13, 2020
Filed:
Jun. 09, 2016
Applicants:
Massachusetts Institute of Technology, Cambridge, MA (US);
Trustees of Boston University, Boston, MA (US);
Inventors:
Ning Mao, Cambridge, MA (US);
Douglas Ewen Cameron, Brookline, MA (US);
James Collins, Newton, MA (US);
Assignees:
Massachusetts Institute of Technology, Cambridge, MA (US);
Trustees of Boston University, Boston, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/569 (2006.01); C07K 14/28 (2006.01); C07K 14/195 (2006.01); C12N 9/12 (2006.01); A61K 35/744 (2015.01); C12N 15/62 (2006.01);
U.S. Cl.
CPC ...
G01N 33/56911 (2013.01); A61K 35/744 (2013.01); C07K 14/195 (2013.01); C07K 14/28 (2013.01); C12N 9/12 (2013.01); C12N 15/62 (2013.01); C12N 15/625 (2013.01); C12Y 305/02006 (2013.01); G01N 2333/28 (2013.01); G01N 2800/26 (2013.01); Y02A 50/52 (2018.01);
Abstract
Provided herein are microorganisms engineered with hybrid receptors and genetic circuits. Also provided are hybrid receptors having a CqsS polypeptide and a heterologous histidine kinase domain of a two-component system. Methods for using engineered microorganisms to sense and destroy pathogens (e.g.,) are also provided.