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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10801879 B1

PDFFull Text
Date of Patent:
Oct. 13, 2020

Filed:

Mar. 21, 2018

Magnesium zinc oxide nanostructure modified biosensor and monitoring of response of cell population to an agent using the same

Applicant:

Rutgers, the State University of New Jersey, New Brunswick, NJ (US);

Inventors:

Yicheng Lu, East Brunswick, NJ (US);

Pavel I. Reyes, New York, NY (US);

Steven Zheng, Watchung, NJ (US);

Andrew Zheng, Watchung, NJ (US);

Keyang Yang, Piscataway, NJ (US);

Assignee:

RUTGERS, THE STATE UNIVERSITY OF NEW JERSEY, New Brunswick, NJ (US);

Attorney:

Fox Rothschild LLP

Primary Examiner:

Jacques M Saint Surin

Int. Cl.
CPC ...
H01L 41/113 (2006.01); H01L 41/187 (2006.01); H01L 41/18 (2006.01); G01N 29/02 (2006.01); G01N 29/46 (2006.01); C12Q 1/04 (2006.01); C12Q 1/02 (2006.01); G01N 33/50 (2006.01); C12M 1/34 (2006.01); G01G 3/13 (2006.01); G01H 11/08 (2006.01); G01H 13/00 (2006.01); G01N 33/483 (2006.01); H01L 41/29 (2013.01); G01G 3/16 (2006.01); B82Y 15/00 (2011.01);
U.S. Cl.
CPC ...
G01G 3/165 (2013.01); C12M 1/34 (2013.01); C12Q 1/025 (2013.01); C12Q 1/04 (2013.01); G01G 3/13 (2013.01); G01H 11/08 (2013.01); G01H 13/00 (2013.01); G01N 29/022 (2013.01); G01N 29/46 (2013.01); G01N 33/4833 (2013.01); G01N 33/5005 (2013.01); G01N 33/5008 (2013.01); H01L 41/1132 (2013.01); H01L 41/18 (2013.01); H01L 41/1871 (2013.01); H01L 41/29 (2013.01); B82Y 15/00 (2013.01); G01N 2291/0256 (2013.01);
Abstract

A magnesium zinc oxide (MZO) nanostructure modified quartz crystal microbalance (MZO-QCM) takes advantage of the unique sensing ability and biocompatibility of MZO-based nanostructures, and combines them with the dynamic impedance spectrum capability of the bulk acoustic wave (BAW) devices including QCM, to form a real-time, noninvasive and label-free cell monitoring biosensor, specifically detecting the susceptibility and resistance of bacterial and fungal strains and cancer cells to various antibiotic and antifungal drugs and anticancer drugs, respectively.

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