The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 13, 2020
Filed:
Mar. 28, 2016
Applicant:
The Scripps Research Institute, La Jolla, CA (US);
Inventors:
Travis Young, La Jolla, CA (US);
Chanhyuk Kim, San Diego, CA (US);
Peter G. Schultz, La Jolla, CA (US);
Assignee:
THE SCRIPPS RESEARCH INSTITUTE, La Jolla, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/705 (2006.01); C07K 7/08 (2006.01); C07K 14/47 (2006.01); A61K 38/00 (2006.01); C12N 9/12 (2006.01); A61K 48/00 (2006.01); C07K 14/725 (2006.01); A61P 35/00 (2006.01); C07K 14/195 (2006.01); C07K 14/32 (2006.01); C07K 14/78 (2006.01); C12N 5/0783 (2010.01); C12N 9/22 (2006.01);
U.S. Cl.
CPC ...
C07K 14/705 (2013.01); C07K 7/08 (2013.01); C07K 14/47 (2013.01); C12Y 207/11011 (2013.01); A61K 38/00 (2013.01); A61K 48/005 (2013.01); A61P 35/00 (2018.01); C07K 14/195 (2013.01); C07K 14/32 (2013.01); C07K 14/7051 (2013.01); C07K 14/70517 (2013.01); C07K 14/70578 (2013.01); C07K 14/78 (2013.01); C07K 2317/522 (2013.01); C07K 2317/524 (2013.01); C07K 2317/526 (2013.01); C07K 2317/53 (2013.01); C07K 2317/55 (2013.01); C07K 2317/56 (2013.01); C07K 2319/00 (2013.01); C07K 2319/02 (2013.01); C07K 2319/03 (2013.01); C07K 2319/20 (2013.01); C07K 2319/70 (2013.01); C12N 5/0636 (2013.01); C12N 9/12 (2013.01); C12N 9/22 (2013.01); C12N 2510/00 (2013.01); C12Y 301/27003 (2013.01);
Abstract
Disclosed herein are switchable chimeric receptors, switchable chimeric receptor effector cells and chimeric receptor effector cell switches. The switchable chimeric receptor-ECs are generally T cells. The chimeric receptors have non-antibody extracellular domains that recognize a chimeric receptor binding partner on the chimeric receptor-EC switch or target cell. The chimeric receptor-ECs and switches may be used for the treatment of a disease or condition in a subject in need thereof.