The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 13, 2020
Filed:
Apr. 17, 2018
Applicant:
Apotex Inc., Toronto, CA;
Inventors:
Prabhudas Bodhuri, San Ramon, CA (US);
Boris Gorin, Oakville, CA;
Melanie R. A. Green, Milton, CA;
Gamini Weeratunga, Ancaster, CA;
Assignee:
Apotex Inc., Toronto, Ontario, CA;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 487/04 (2006.01); B01J 31/22 (2006.01);
U.S. Cl.
CPC ...
C07D 487/04 (2013.01); B01J 31/2295 (2013.01);
Abstract
The present invention provides processes for the preparation of Acalabrutinib (1), as well as intermediates useful in the preparation thereof. In particular, processes are provided for coupling of a compound of Formula (5) and 2-butynoic acid in the presence of Carbodiimide (8) to afford Acalabrutinib (1).