Substituted naphtho[2,3-b]furans as water-soluble prodrugs for preventing and/or treating cancer

Abstract

The present invention provides compounds represented by formula (1A), or pharmaceutically acceptable salts. Compounds represented by formula (1A), or pharmaceutically acceptable salts thereof, wherein Aand Aare identical or different, and each independently —C(═O)B, —C(═O)CRRB, —COB, —C(═S)OB, —CONRB, —C(═S)NRB, a hydrogen atom, or the like, wherein Aand Aare not both hydrogen atoms, wherein B is an optionally substituted 3- to 12-membered monocyclic or polycyclic heterocyclic group, an optionally substituted 3- to 12-membered cyclic amino group, or a group represented by the following formula (B), wherein the 3- to 12-membered monocyclic or polycyclic heterocyclic group and the 3- to 12-membered cyclic amino group have at least one or more secondary nitrogen atoms in the ring; Ris a hydrogen atom or the like; R, R, R, and Rare identical or different, and each independently a hydrogen atom or the like; and Ris alkyl. wherein * denotes a bonding position.