The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 13, 2020
Filed:
Apr. 22, 2016
Applicant:
The Johns Hopkins University, Baltimore, MD (US);
Inventors:
Tian-Li Wang, Clarksville, MD (US);
Ie-Ming Shih, Clarksville, MD (US);
Mark Vaal, Perry Hall, MD (US);
Alexander Stoeck, Washington, DC (US);
Jin G. Jung, Towson, MD (US);
Assignee:
The Johns Hopkins University, Baltimore, MD (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C 237/40 (2006.01); C07D 215/38 (2006.01); A61K 31/167 (2006.01); A61K 31/47 (2006.01); A61P 35/00 (2006.01); C07D 215/16 (2006.01); C07D 215/20 (2006.01); C07D 311/64 (2006.01); A61P 25/28 (2006.01); A61P 29/00 (2006.01); C07C 311/21 (2006.01);
U.S. Cl.
CPC ...
C07D 215/38 (2013.01); A61K 31/167 (2013.01); A61K 31/47 (2013.01); A61P 25/28 (2018.01); A61P 29/00 (2018.01); A61P 35/00 (2018.01); C07C 237/40 (2013.01); C07C 311/21 (2013.01); C07D 215/16 (2013.01); C07D 215/20 (2013.01); C07D 311/64 (2013.01);
Abstract
In accordance with one or more embodiments, the present invention provides a compound of formulas I, II, and III, for use in methods of inhibition of PBX1-DNA interaction in a mammalian cell or population of cells, and for use in the treatment of medical conditions including but not limited to cancers, developmental disorders, inflammatory disorders, autoimmune diseases, or neuro-degenerative disorders.