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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10800739 B1

PDFFull Text
Date of Patent:
Oct. 13, 2020

Filed:

Jul. 02, 2019

4-carboxamido-isoindolinone derivatives as selective parp-1 inhibitors

Applicant:

Nerviano Medical Sciences S.r.l, Nerviano (MI), IT;

Inventors:

Gianluca Mariano Enrico Papeo, Cernusco Lombardone, IT;

Mikhail Yurievitch Krasavin, Nathan, AU;

Paolo Orsini, Legnano, IT;

Alessandra Scolaro, Bresso, IT;

Assignee:

NERVIANO MEDICAL SCIENCES S.R.L., Nerviano (MI), IT;

Attorney:

Scully, Scott, Murphy & Presser, P.C.

Primary Examiner:

David K O'Dell

Int. Cl.
CPC ...
A61K 31/4035 (2006.01); C07D 209/44 (2006.01); C07D 401/06 (2006.01); C07D 209/46 (2006.01); C07D 401/14 (2006.01); C07D 403/02 (2006.01); C07D 403/04 (2006.01); C07D 403/14 (2006.01); C07D 405/04 (2006.01); C07D 405/14 (2006.01); C07D 407/14 (2006.01); C07D 409/14 (2006.01); C07D 413/06 (2006.01); C07D 413/14 (2006.01); A61K 31/4188 (2006.01); A61K 31/4439 (2006.01); A61K 31/454 (2006.01); A61K 31/4725 (2006.01); A61K 31/496 (2006.01); A61K 31/5377 (2006.01);
U.S. Cl.
CPC ...
C07D 209/44 (2013.01); A61K 31/4035 (2013.01); A61K 31/4188 (2013.01); A61K 31/4439 (2013.01); A61K 31/454 (2013.01); A61K 31/4725 (2013.01); A61K 31/496 (2013.01); A61K 31/5377 (2013.01); C07D 209/46 (2013.01); C07D 401/06 (2013.01); C07D 401/14 (2013.01); C07D 403/02 (2013.01); C07D 403/04 (2013.01); C07D 403/14 (2013.01); C07D 405/04 (2013.01); C07D 405/14 (2013.01); C07D 407/14 (2013.01); C07D 409/14 (2013.01); C07D 413/06 (2013.01); C07D 413/14 (2013.01);
Abstract

There are provided substituted 4-carboxamido-isoindolinone derivatives which selectively inhibit the activity of poly (ADP-ribose) polymerase PARP-I with respect to poly (ADP-ribose) polymerase P ARP-2. The compounds of this invention are therefore useful in treating diseases such as cancer, cardiovascular diseases, central nervous system injury and different forms of in-flammation. The present invention also provides methods for preparing these compounds, pharmaceutical compositions comprising these compounds, and methods of treating diseases utilizing pharmaceutical compositions comprising these compounds.

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