The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 13, 2020
Filed:
Jun. 10, 2015
3b Pharmaceuticals Gmbh, Berlin, DE;
Frank Osterkamp, Berlin, DE;
Christian Haase, Berlin, DE;
Ulrich Reineke, Berlin, DE;
Christiane Smerling, Berlin, DE;
Matthias Paschke, Berlin, DE;
Jan Ungewiß, Berlin, DE;
3B Pharmaceuticals GMBH, Berlin, DE;
Abstract
The present invention is related to a conjugate comprising a structure of general formula (1) [TM1]-[AD1]-[LM]-[AD2]-[TM2] (1), wherein TM1 is a first targeting moiety, wherein the first targeting moiety is capable of binding to a first target, AD1 is a first adapter moiety or is absent, LM is a linker moiety or is absent, AD2 is a second adapter moiety or is absent, and TM2 is a second targeting moiety, wherein the second targeting moiety is capable of binding to a second target; wherein the first targeting moiety and/or the second targeting moiety is a compound of formula (2): wherein Ris selected from the group consisting of hydrogen, methyl and cyclopropylmethyl; AA-COOH is an amino acid selected from the group consisting of 2-amino-2 adamantane carboxylic acid, cyclohexylglycine and 9-amino-bicyclo[3.3.1]nonane-9 carboxylic acid; Ris selected from the group consisting of (C-C)alkyl, (C-C)cycloalkyl, (CC)cycloalkylmethyl, halogen, nitro and trifluoromethyl; ALK' is (C-C)alkylidene; R, Rand Rare each and independently selected from the group consisting of hydrogen and (C-C)alkyl under the proviso that one of R, Rand Ris of the following formula (3) wherein ALK′ is (C-C)alkylidene; Ris selected from the group consisting of hydrogen and (C-C)alkyl; and Ris a bond; or a pharmacologically acceptable salt, solvate or hydrate thereof.