The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 13, 2020

Filed:

Aug. 09, 2018
Applicant:

Northwestern University, Evanston, IL (US);

Inventors:

Irina Budunova, Chicago, IL (US);

Alexander Yemelyanov, Chicago, IL (US);

Assignee:

Northwestern University, Evanston, IL (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/396 (2006.01); A61K 31/135 (2006.01); A61K 31/216 (2006.01); C07C 229/38 (2006.01); A61K 31/222 (2006.01); A61K 45/06 (2006.01); C12Q 1/6886 (2018.01); G01N 33/574 (2006.01);
U.S. Cl.
CPC ...
A61K 31/396 (2013.01); A61K 31/135 (2013.01); A61K 31/216 (2013.01); A61K 31/222 (2013.01); A61K 45/06 (2013.01); C07C 229/38 (2013.01); C12Q 1/6886 (2013.01); G01N 33/57434 (2013.01); C12Q 2600/158 (2013.01);
Abstract

Disclosed are methods and pharmaceutical compositions for modulating one or more steroidal receptor activities. The methods typically utilize and the pharmaceutical compositions typically include one or more substituted phenyl aziridine precursors, their respective aziridines, analogs thereof, derivatives thereof, or pharmaceutically acceptable salts thereof such as CpdA. The methods and compositions may be used for treating diseases, disorders, and conditions associated with glucocorticoid receptor activity, androgen receptor activity, or both, such as cancers, acne vulgaris, and alopecia.


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