The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 13, 2020
Filed:
Jun. 15, 2016
Applicant:
University of Washington, Seattle, WA (US);
Inventors:
Rodney J. Y. Ho, Seattle, WA (US);
Jennifer Iwamoto, Seattle, WA (US);
Assignee:
University of Washington, Seattle, WA (US);
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/127 (2006.01); A61K 9/14 (2006.01); A61K 9/51 (2006.01); A61K 31/427 (2006.01); A61K 31/513 (2006.01); A61K 31/536 (2006.01); A61K 31/5365 (2006.01); A61K 31/675 (2006.01); A61K 31/7072 (2006.01); A61K 47/24 (2006.01);
U.S. Cl.
CPC ...
A61K 9/127 (2013.01); A61K 9/14 (2013.01); A61K 9/5123 (2013.01); A61K 31/427 (2013.01); A61K 31/513 (2013.01); A61K 31/536 (2013.01); A61K 31/5365 (2013.01); A61K 31/675 (2013.01); A61K 31/7072 (2013.01); A61K 47/24 (2013.01);
Abstract
Provided are multi-drug lipid nanoparticles that stably incorporate multiple small molecule drugs with divergent hydrophobic and water solubility characteristics and related methods of making and using the same, The disclosed compositions and methods provide for enhanced stability of lipid nanoparticle drug formulations that can reliably provide drugs addressing different mechanistic targets with prolonged presence in the body for more efficacious treatment and avoidance of single drug resistance.