The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 06, 2020

Filed:

Feb. 04, 2016
Applicant:

President and Fellows of Harvard College, Cambridge, MA (US);

Inventor:

Ping Xie, Needham, MA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/487 (2006.01); C12Q 1/6869 (2018.01); G01N 27/414 (2006.01); B01L 3/00 (2006.01); G01N 27/416 (2006.01); G01N 27/447 (2006.01);
U.S. Cl.
CPC ...
G01N 33/48721 (2013.01); B01L 3/50273 (2013.01); B01L 3/502715 (2013.01); C12Q 1/6869 (2013.01); G01N 27/4145 (2013.01); G01N 27/4146 (2013.01); G01N 27/4163 (2013.01); G01N 27/4473 (2013.01); G01N 27/44726 (2013.01); G01N 27/44791 (2013.01); B01L 2300/0645 (2013.01); B01L 2300/0867 (2013.01); B01L 2300/0896 (2013.01); B01L 2300/12 (2013.01); B01L 2400/0421 (2013.01);
Abstract

A nanopore sensor is provided, including a nanopore disposed in a support structure. A fluidic passage is disposed between a first fluidic reservoir and the nanopore to fluidically connect the first fluidic reservoir to the nanopore through the fluidic passage. The fluidic passage has a passage length that is greater than the passage width. A second fluidic reservoir is fluidically connected to the nanopore, with the nanopore providing fluidic communication between the fluidic passage the second reservoir. Electrodes are connected to impose an electrical potential difference across the nanopore. At least one electrical transduction element is disposed in the nanopore sensor with a connection to measure the electrical potential that is local to the fluidic passage.


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