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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10793826 B1

PDFFull Text
Date of Patent:
Oct. 06, 2020

Filed:

Jan. 27, 2016

Genetically modified microorganisms having improved tolerance towards l-serine

Applicant:

Cysbio Aps, Kgs. Lyngby, DK;

Inventors:

Hemanshu Mundhada, Kgs. Lyngby, DK;

Alex Toftgaard Nielsen, Rungsted Kyst, DK;

Assignee:

CysBio Aps, Kgs. Lyngby, DK;

Attorney:

Knobbe Martens Olson & Bear LLP

Primary Examiner:

Richard G Hutson

Int. Cl.
CPC ...
C12N 1/20 (2006.01); C12P 13/00 (2006.01); C12N 1/36 (2006.01); C12P 13/06 (2006.01); C12N 9/04 (2006.01); C12N 9/10 (2006.01); C12N 9/12 (2006.01); C12N 9/16 (2006.01); C12N 9/88 (2006.01); C12N 15/52 (2006.01); C12N 9/90 (2006.01); C12P 17/16 (2006.01); C12P 13/22 (2006.01); C12N 15/01 (2006.01); C12P 13/12 (2006.01); C07K 14/245 (2006.01); C12N 9/00 (2006.01); C07K 14/32 (2006.01);
U.S. Cl.
CPC ...
C12N 1/36 (2013.01); C07K 14/245 (2013.01); C07K 14/32 (2013.01); C12N 1/20 (2013.01); C12N 9/0006 (2013.01); C12N 9/1014 (2013.01); C12N 9/1096 (2013.01); C12N 9/1205 (2013.01); C12N 9/1217 (2013.01); C12N 9/1247 (2013.01); C12N 9/16 (2013.01); C12N 9/88 (2013.01); C12N 9/90 (2013.01); C12N 9/93 (2013.01); C12N 15/01 (2013.01); C12N 15/52 (2013.01); C12P 13/001 (2013.01); C12P 13/06 (2013.01); C12P 13/12 (2013.01); C12P 13/22 (2013.01); C12P 17/165 (2013.01); C12P 17/167 (2013.01); C12Y 101/01003 (2013.01); C12Y 101/01095 (2013.01); C12Y 201/02001 (2013.01); C12Y 206/01052 (2013.01); C12Y 207/02003 (2013.01); C12Y 301/03003 (2013.01); C12Y 403/01017 (2013.01);
Abstract

The present invention generally relates to the microbiological industry, and specifically to the production of L-serine or L-serine derivatives using genetically modified bacteria. The present invention provides genetically modified microorganisms, such as bacteria, wherein the expression of genes encoding for enzymes involved in the degradation of L-serine is attenuated, such as by inactivation, which makes them particularly suitable for the production of L-serine at higher yield. The present invention also provides means by which the microorganism, and more particularly a bacterium, can be made tolerant towards higher concentrations of serine. The present invention also provides methods for the production of L-serine or L-serine derivative using such genetically modified microorganisms.

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