The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 06, 2020
Filed:
Aug. 30, 2018
Duquesne University of the Holy Spirit, Pittsburgh, PA (US);
Wayne State University, Detroit, MI (US);
Aleem Gangjee, Allison Park, PA (US);
Larry H. Matherly, Novi, MI (US);
Duquesne University of The Holy Spirit, Pittsburgh, PA (US);
Wayne State University, Detroit, MI (US);
Abstract
A compound of the Formula I and optionally a pharmaceutically acceptable salt thereof is provided: Formula I, wherein, R is one selected from the group consisting of H and CH;n is an integer ranging from 1 to 4; X is one selected from the group consisting of —CH—, O, S, —NH—, —NHCHO—, —NHCOCH—, and —NHCOCF—; and Ar is one selected from the group consisting of (a) 1,4-phenyl, (b) 2'-fluoro-1,4-phenyl, and (c) 2,5-thienyl. Methods of treating a patient having cancer, targeting mitochondrial metabolism, and targeting SHMT2 and MTHFD2 using the compounds of this invention are disclosed.