The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 06, 2020
Filed:
Apr. 01, 2019
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Michael D. Altman, Needham, MA (US);
Brandon D. Cash, Stoughton, MA (US);
Matthew Lloyd Childers, Medfield, MA (US);
Jared N. Cumming, Winchester, MA (US);
Duane E. DeMong, Hanover, MA (US);
Andrew Marc Haidle, Somerville, MA (US);
Timothy J. Henderson, Natick, MA (US);
James P. Jewell, Newton, MA (US);
Matthew A. Larsen, Dedham, MA (US);
Jongwon Lim, Lexington, MA (US);
Min Lu, Brookline, MA (US);
Ryan D. Otte, Natick, MA (US);
Benjamin Wesley Trotter, Medfield, MA (US);
Merck Sharp & Dohme Corp., Rahway, NJ (US);
Abstract
Compounds of general formula (I), of general formula (II), of general formula (III), of general formula (IV), of general formula (V), of general formula (VI), and their pharmaceutically acceptable salts, wherein all variables are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are compositions comprising such compounds, processes for the synthesis of such compounds, and to uses of such compounds, including administration of such compounds to induce immune response, to induce STING-dependent type I interferon production, and/or to treat a cell proliferation disorder, such as cancer.