The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Oct. 06, 2020

Filed:

Aug. 31, 2017
Applicant:

The Board of Regents of the University of Texas System, Austin, TX (US);

Inventors:

Nageswari Yarravarapu, Dallas, TX (US);

Chuo Chen, Dallas, TX (US);

Lawrence Lum, Dallas, TX (US);

Lin You, Dallas, TX (US);

Chengwei Zhang, Dallas, TX (US);

Xiaolei Wang, Dallas, TX (US);

Lishu Zhang, Dallas, TX (US);

Assignee:

Other;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 409/14 (2006.01); A61K 31/4192 (2006.01); C07D 405/14 (2006.01); A61K 31/506 (2006.01); A61K 31/4439 (2006.01); A61K 31/444 (2006.01); A61K 45/06 (2006.01); C07D 255/02 (2006.01);
U.S. Cl.
CPC ...
C07D 401/12 (2013.01); A61K 31/4192 (2013.01); A61K 31/444 (2013.01); A61K 31/4439 (2013.01); A61K 31/506 (2013.01); A61K 45/06 (2013.01); C07D 255/02 (2013.01); C07D 401/14 (2013.01); C07D 405/14 (2013.01); C07D 409/14 (2013.01);
Abstract

The present disclosure provides compounds that may be useful for inhibiting Wnt pathway comprising compounds of the formula: (Ia) or (Ib) wherein the variables are as defined herein. In some aspects, the compounds may be used to inhibit the Wnt pathway and used to treat cancer, myocardial infarction, osteopetrosis, or used in the maturation of a precursor cell to a mature cell. Also provided herein in are pharmaceutical compositions of the compounds described herein.


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