The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 06, 2020
Filed:
Sep. 11, 2017
Applicant:
Bayer Pharma Aktiengesellschaft, Berlin, DE;
Inventors:
Johannes Platzek, Berlin, DE;
Wilhelm Trentmann, Münster, DE;
Assignee:
BAYER PHARMA AKTIENGESELLSCHAFT, Berlin, DE;
Primary Examiner:
Int. Cl.
CPC ...
C07D 257/02 (2006.01);
U.S. Cl.
CPC ...
C07D 257/02 (2013.01); C07B 2200/13 (2013.01);
Abstract
A method is described for production of a high purity compound of the formula (I) in crystalline form of the modification A. In this, starting from high purity gadobutrol, the gadolinium is removed by decomplexation with oxalic acid, and then with a calcium salt the calcium complex is produced in high purity. During the crystallization, a water equivalent of 9-11 weight % is set. The crystalline form of the modification A of the compound of the formula (I) is used in the production of Gadovist.