The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 06, 2020
Filed:
Jul. 27, 2018
Applicant:
Genzyme Corporation, Cambridge, MA (US);
Inventor:
James Stefano, Hopkinton, MA (US);
Assignee:
Genzyme Corporation, Cambridge, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/47 (2006.01); A61K 47/60 (2017.01); A61K 47/61 (2017.01); A61K 47/64 (2017.01); C12N 9/40 (2006.01); C12N 9/96 (2006.01); A61P 43/00 (2006.01); A61P 3/00 (2006.01);
U.S. Cl.
CPC ...
A61K 38/47 (2013.01); A61K 47/60 (2017.08); A61K 47/61 (2017.08); A61K 47/64 (2017.08); C12N 9/2465 (2013.01); C12N 9/96 (2013.01); C12Y 302/01022 (2013.01);
Abstract
Methods of making ligand-decorated polymer conjugates of therapeutic glycoproteins are described. Improved targeting of glycoproteins to specific tissues is achieved by masking the natural carbohydrate and other surface determinants with high molecular weight polymers, such as, e.g., PEG, polysialic acid, etc., which in turn are decorated with target-specific ligands. In some embodiments, acid-labile linkages in such conjugates or rapidly degradable masking groups allow for the intracellular release of the polymer from the glycoprotein, for example, under conditions found in lysosomes.