The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Oct. 06, 2020
Filed:
Jul. 15, 2016
Applicant:
Children's National Medical Center, Washington, DC (US);
Inventors:
Marshall Summar, Washington, DC (US);
Juan Cabrera-Luque, Washington, DC (US);
Gary Cunningham, Washington, DC (US);
Dione T. Kobayashi, Boston, MA (US);
James G. McArthur, Concord, MA (US);
Assignee:
CHILDREN'S NATIONAL MEDICAL CENTER, Washington, DC (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/44 (2006.01); C12N 9/00 (2006.01); A61K 38/51 (2006.01); A61K 31/708 (2006.01); A61K 31/195 (2006.01); A61K 9/48 (2006.01); A61K 45/06 (2006.01); C12N 9/06 (2006.01); A61K 31/7084 (2006.01); A61K 9/00 (2006.01);
U.S. Cl.
CPC ...
A61K 38/44 (2013.01); A61K 9/0053 (2013.01); A61K 9/4891 (2013.01); A61K 31/195 (2013.01); A61K 31/7084 (2013.01); A61K 38/51 (2013.01); A61K 45/06 (2013.01); C12N 9/0014 (2013.01); C12Y 104/0102 (2013.01); C12Y 403/01024 (2013.01);
Abstract
The present invention provides compositions and methods of treating hyperphenylalaninemia (e.g., phenylketonuria) in a subject in need thereof comprising administering to the subject an effective amount of a phenylalanine dehydrogenase (PheDH) polypeptide. The present invention also provides pharmaceutical formulations comprising PheDH for lowering the phenylalanine concentration in the subject (e.g., in the intestines and/or blood).