The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 29, 2020
Filed:
May. 28, 2019
Applicant:
Icahn School of Medicine AT Mount Sinai, New York, NY (US);
Inventors:
Barbara Murphy, Pelham Manor, NY (US);
Weijia Zhang, Cresskill, NJ (US);
Assignee:
Icahn School of Medicine at Mount Sinai, New York, NY (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/04 (2006.01); C12Q 1/6883 (2018.01); A61K 38/18 (2006.01); A61K 38/17 (2006.01); A61K 38/13 (2006.01); A61K 31/573 (2006.01); A61K 31/5377 (2006.01); A61K 31/52 (2006.01); A61K 38/22 (2006.01); C07K 14/705 (2006.01); A61K 31/343 (2006.01); A61K 31/436 (2006.01); A61K 31/4412 (2006.01);
U.S. Cl.
CPC ...
C12Q 1/6883 (2013.01); A61K 31/343 (2013.01); A61K 31/436 (2013.01); A61K 31/4412 (2013.01); A61K 31/52 (2013.01); A61K 31/5377 (2013.01); A61K 31/573 (2013.01); A61K 38/13 (2013.01); A61K 38/1774 (2013.01); A61K 38/18 (2013.01); A61K 38/1875 (2013.01); A61K 38/2221 (2013.01); C07K 14/70521 (2013.01); C07K 2319/30 (2013.01); C12Q 2600/118 (2013.01); C12Q 2600/158 (2013.01); C12Q 2600/178 (2013.01); G01N 2800/245 (2013.01); G01N 2800/347 (2013.01); G01N 2800/52 (2013.01);
Abstract
Disclosed herein is a method for diagnosing a renal allograft recipient's risk for developing fibrosis of the allograft and allograft loss. The method includes determining the expression levels of certain microRNAs, which have been determined to be predictive of an allograft recipient's risk. Also disclosed herein is a method of treating a renal allograft recipient to inhibit fibrosis of the allograft and allograft loss, as well as kits for use in the methods disclosed herein.