The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 29, 2020
Filed:
Oct. 07, 2013
Pfizer Inc., New York, NY (US);
Jason Arnold Lotvin, Thiells, NY (US);
Annaliesa Sybil Anderson, Upper Saddle River, NJ (US);
Robert G. K. Donald, South Orange, NJ (US);
Michael James Flint, Decatur, GA (US);
Narender Kumar Kalyan, Ridgewood, NJ (US);
Kathrin Ute Jansen, New York, NY (US);
Maninder K. Sidhu, New City, NY (US);
Justin Keith Moran, West Nyack, NY (US);
Mark Edward Ruppen, Garnerville, NY (US);
Weiqiang Sun, Morristown, NJ (US);
Pfizer Inc., New York, NY (US);
Abstract
In one aspect, the invention relates to an immunogenic composition that includes a mutanttoxin A and/or a mutanttoxin B. The mutant toxin may include a glucosyltransferase domain having at least one mutation and a cysteine protease domain having at least one mutation, relative to the corresponding wild-typetoxin. The mutant toxins may include at least one amino acid that is chemically crosslinked. In another aspect, the invention relates to methods and compositions for use in culturingand in producingtoxins.