The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 29, 2020
Filed:
Apr. 22, 2016
Applicant:
Baylor College of Medicine, Houston, TX (US);
Inventors:
Maksim Mamonkin, Pearland, TX (US);
Malcolm K. Brenner, Bellaire, TX (US);
Assignee:
Baylor College of Medicine, Houston, TX (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/17 (2006.01); A61K 45/06 (2006.01); C07K 14/725 (2006.01); C07K 14/705 (2006.01); C07K 16/28 (2006.01); C12N 5/0783 (2010.01); A61K 35/17 (2015.01); A61P 35/02 (2006.01); A61K 39/395 (2006.01); C07K 14/715 (2006.01); C07K 16/30 (2006.01);
U.S. Cl.
CPC ...
A61K 38/1774 (2013.01); A61K 35/17 (2013.01); A61K 39/395 (2013.01); A61K 45/06 (2013.01); A61P 35/02 (2018.01); C07K 14/7051 (2013.01); C07K 14/70521 (2013.01); C07K 14/715 (2013.01); C07K 16/2896 (2013.01); C07K 16/30 (2013.01); C12N 5/0636 (2013.01); C07K 2317/622 (2013.01); C07K 2317/92 (2013.01); C07K 2317/94 (2013.01); C07K 2319/03 (2013.01);
Abstract
Embodiments of the disclosure include methods and compositions related to immunotherapy that targets CD5. In particular embodiments, immune cells engineered to comprise a chimeric antigen receptor (CAR) that targets CD5 are contemplated, and uses thereof. In particular embodiments, the immune cells expressing the CAR do not commit fratricide to any great extent against T cells that express CD5 and which are endogenous to an individual receiving the immune cells.