The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 29, 2020
Filed:
Sep. 22, 2016
Applicant:
The Johns Hopkins University, Baltimore, MD (US);
Inventors:
Nazareno Paolocci, Baltimore, MD (US);
Ning Feng, Baltimore, MD (US);
Carlo G. Tocchetti, Baltimore, MD (US);
Cyrus Takahashi, Baltimore, MD (US);
Bruce Carter, Nashville, TN (US);
Assignees:
The Johns Hopkins University, Baltimore, MD (US);
Vanderbilt University, Nashville, TN (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/08 (2019.01); A61K 38/10 (2006.01); A61K 45/06 (2006.01); G01N 33/50 (2006.01); C07K 7/06 (2006.01); C07K 7/08 (2006.01); C07K 14/475 (2006.01); A61P 9/00 (2006.01); A61K 38/12 (2006.01); A61K 49/00 (2006.01);
U.S. Cl.
CPC ...
A61K 38/08 (2013.01); A61K 38/10 (2013.01); A61K 38/12 (2013.01); A61K 45/06 (2013.01); A61K 49/0004 (2013.01); A61P 9/00 (2018.01); C07K 7/06 (2013.01); C07K 7/08 (2013.01); C07K 14/475 (2013.01); G01N 33/502 (2013.01); G01N 33/5061 (2013.01); G01N 33/5082 (2013.01); G01N 2800/325 (2013.01);
Abstract
The present invention provides 75 kD transmembrane neurotrophin receptor (p75) antagonists and their use in prevention and treatment of loss of function, and adverse remodeling, in cardiac tissues subject to acute or chronic hemodynamic stress. Uses of the antagonists with or without additional cardiotropic agents for improving contractility and for treatment of congestive heart failure are also provided.